Symptoms of schizophrenia and bipolar 1 disorder can present in the adolescent years, making early assessment and effective treatment crucial to daily function and quality of life. The multiple genetic and environmental risks at play, along with high levels of suicidal ideation and suicidal behavior, underscore the need for clinical understanding of these psychiatric disorders. Both come with treatment adherence and medication management challenges, which are often complicated by medical comorbidities.

This Clinician Guide provides a look at the DSM-5 diagnostic criteria for assessing bipolar 1 disorder and schizophrenia, current treatment guidelines, and practical perspectives from clinicians on how to manage the unique challenges associated these mental health disorders.

Understanding Bipolar 1 Disorder

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Bipolar Disorder DSM Diagnostic Criteria

Bipolar 1 Disorder Prevalence and Risks (Data Slideshow)

Understanding Schizophrenia

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Schizophrenia: DSM-5 Definition

Schizophrenia: Age of Onset and Racial Disparities (Data Slideshow)

Treatment Guidelines for Bipolar 1 and Schizophrenia

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Bipolar 1 Disorder Treatment: Current Guidelines and Approaches

Bipolar Depression Treatment: Urgent and First-Line Approaches

Schizophrenia Treatment: Updated Guidelines on First-Line Medication and Psychosocial Approaches

First and Second-Generation Antipsychotics

Current Medication Management and Emerging Pharmacologic Treatment Options for Schizophrenia and Bipolar I Disorder: A 5-part Literature Review


Medication Management: Clinical Challenges & Perspectives

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Assessment & Treatment Considerations

Clinical Challenges in Diagnosing Bipolar Disorder, with Chris Aiken, MD

Is it Unipolar or Bipolar Depression? Asking the right assessment questions, by Sarah W. Strang, RN, APN-BC

Medical Marijuana as a Potential Schizophrenia Treatment, with Julie Foster, FNP, MSN, Marc Manseau, MD, MPH

Schizophrenia and Cognitive Remediation, with Antonio Vita, MD, PhD

Addressing Suicidal Ideation in Patients with Schizophrenia, with Kelly L. Green, PhD, and Dr. Sidney Zisook, MD

Managing Schizophrenia during COVID: How One Psychiatric Nurse Makes the Most of Teletherapy

Weight Gain in Adolescents on Antidepressants, with Lea Lis, MD

Ethnopsychopharmacology: The importance of metabolism in prescribing antipsychotics

See also, an updated Literature Review: Medication Management and Pharmacologic Options for Schizophrenia and Bipolar I Disorder


Overlapping Medical Conditions and Mental Health, with George Fragoulis, Carra Simpson, PhD, John R. Kelly, MD, and Christoph Correll, MD

Prescribing Considerations for Bipolar Spectrum and Pain, with Lawrence Robbins, MD

Schizophrenia and Diabetes: A Look at Genetic Predisposition and Antipsychotics, with Zachary Freyberg, MD, PhD, Toby Pillinger, PhD, MRCP, Elena Christofides, MD, FACE

Schizophrenia and Sleep Disorders, with Zachary Freyberg, MD, PhD, Dimitri Markov, MD

Schizophrenia and PTSD (A Data Slideshow)


Last Updated: Sep 1, 2021